Benefits of Humaneering® Antibodies

This process for engineering antibodies results in sequences very close and in some cases identical to human germline. The property of closeness-to-human-germline (and not merely 'fully human') has implications beyond immunogenicity. Unlike other technologies, Humaneering® yields large panels of antibodies with the identical binding specificity; therefore, clones can be chosen that fulfill not only classic issues of antibody engineering (e.g., affinity and specificity), but also downstream processing issues (e.g., expression level, stability, etc.) as shown below:

V-region Sequences

  • High amino-acid sequence identity with human germ-line, including CDRs 1+2 from each chain
  • V-regions sequences are mainly from a human source and are close to germline in sequence
  • CDR lengths and sequences are 'natural'
  • Important for low immunogenicity

Affinity

  • Binding affinity and selectivity is high
  • Kinetics on/off rates can be selected
  • Important for potency/dose/cost of goods

Expression Level

  • Antibodies are screened for high level expression
  • Important for cost of goods

Physicochemical Properties

  • Mainly determined by V-region sequences
  • Solubility, stability and lack of aggregation
  • Important for low immunogenicity, cost of goods and route of delivery
You are now leaving this website. If you would like to continue, click Continue.
CancelContinue